Clinical Evidence & Publications

The research behind U: The Mind Company.

Peer-reviewed research, clinical trial data, and our full safety profile, all publicly traceable.

Parkinson's Disease

RESTORE Trial · Preprint · March 2026 · n=26

RESTORE Trial Results

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Up to 64%
improvement in UPDRS scores within three weeks
Up to 67%
reduction in tremor amplitude
Up to 77%
reduction in pathological tremor-band power
0
serious adverse events

Alzheimer's Disease

Peer-Reviewed · IntechOpen 2024 · n=5 · 12 weeks

Frontal Lobe Electrical Stimulation Enhances Connectivity in Alzheimer's Disease Networks: Evidence from rs-fMRI

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580%
increase in hippocampal activation after 12 weeks
5,400%
increase in temporal pole activation after 12 weeks
Enhanced
Default Mode and Salience Network connectivity
0
serious adverse events

Safety Profile

2,000,000+
treatment minutes
250+
people studied
0
serious adverse events across all studies

Most common side effect: mild, transient tingling at the electrode sites.

All Publications

1

Publication

The Biological Basis of Parkinson's Disease.

2

Peer-Reviewed | IntechOpen 2024

Frontal Lobe Electrical Stimulation Enhances Connectivity in Alzheimer's Disease Networks: Evidence from rs-fMRI.

View →
3

Publication

Advanced Computer Vision and Signal Processing for Quantitative Tremor and Gait Analysis in Parkinson's Disease: A Case Study.

4

Publication

Toward EEG Digital Twins: Channel-wise Nonlinear State Estimation with the Unscented Kalman Filter and Jansen-Rit Model.

5

Publication

Behavioral Biomarkers for Parkinson's Disease: Bradykinesia, REM Sleep Behavior Disorder, and Hyposmia as Key Clinical Indicators.

6

Publication

The Role of PRKN Biallelic Loss-of-Function Variants in Parkinson's Disease: A Comprehensive Review.

7

Publication

Alpha-Synuclein Seed Amplification Assay (alphaSyn-SAA) in Parkinson's Disease: A Transformative Cellular Biomarker for Early Detection and Disease Monitoring.

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