Electrical Stimulation for Parkinson's Disease
Parkinson's Disease (PD) is a central nervous system disorder characterized by movement abnormalities such as tremors, rigidity, and gait freezing. The major hypothesis for the cause of PD is the reduction in dopaminergic neurons in the substantia nigra. The main association tract connecting the substantia nigra to the spinal cord and motor cortex , the corticospinal tract, has been identified as having impairment in PD patients. U sends packets of electrical stimuli along these tracts to ameliorate PD symptoms.
Targeting the Corticospinal Tract
Our amplitude-modulated transcranial pulsed current stimulation (am-tPRNS) technology delivers targeted electrical pulses non-invasively through the scalp, along the corticospinal tract — the primary motor pathway affected in Parkinson's disease.
Unlike deep brain stimulation, no surgery is required. People use the device at home in 20-minute daily sessions, with results building over weeks as neuroplastic changes accumulate.
Trial Results
Three published case studies documenting the safety and efficacy of electrical stimulation for Parkinson's disease motor symptoms.
Medication-Induced Dyskinesia: A 15-Day Electrical Stimulation Trial
A 57-year-old male with Parkinson's disease underwent a 15-day treatment of transcranial pulsed current stimulation. Quantitative analysis showed improvements in postural tremor and medication-induced dyskinesia.
- ✓Postural tremor amplitude decreased by 7.59%
- ✓Consistent 4–6 Hz dominant frequencies maintained
- ✓Dyskinesia reduced 33.44% to 62.25% across all body parts
- ✓Novel video hand-tracking provided objective measurements
Combined results demonstrated consistent improvements in both postural tremor and dyskinesia, suggesting electrical stimulation as a promising non-invasive treatment for Parkinson's motor symptoms.
Bradykinesia and Freezing of Gait: An 84-Day Electrical Stimulation Trial
A 76-year-old patient with a 6-year history of Parkinson's underwent a 12-week electrical stimulation trial after experiencing limited benefits from traditional medications. The patient completed 84 daily 20-minute sessions at home.
- ✓Improvements in gait, speech, and freezing episodes
- ✓No falls or incontinence incidents reported
- ✓Only mild, transient side effects throughout trial
- ✓All 84 daily sessions completed at home independently
This case suggests electrical stimulation could be a safe and promising adjunctive therapy for Parkinson's disease bradykinesia and freezing of gait.
Resting Tremor: A 5-Day Electrical Stimulation Trial
A case study published in Clinical and Experimental Psychology focused on a 76-year-old female patient with Stage IV Parkinson's Disease with resting tremor. Over five days, the patient received 20-minute daily am-tPRNS sessions targeting the motor cortex along the corticospinal tract.
- ✓Estimated 80% reduction in resting hand tremor amplitude
- ✓73.5% improvement in UPDRS scores
- ✓Only mild, non-adverse effects reported
- ✓Study conducted by U: The Mind Company and ASLEK Epilepsy
Published in Clinical and Experimental Psychology. Link: iomcworld.org/open-access/case-report-of-transcranial-pulsedcurrent-stimulation-with-parkinsons-disease.pdf This study suggests electrical stimulation could be a safe and effective adjunctive therapy for Parkinson\'s disease.
Investigational Device Notice: Subjects in these videos participated in IRB-approved studies or equivalent medical oversight while using our investigational devices, which are not FDA-cleared or available for sale. Informed consent and video-release forms were obtained. Videos are for informational purposes only and do not guarantee outcomes. INVESTIGATIONAL DEVICE, LIMITED BY UNITED STATES LAW TO INVESTIGATIONAL USE. NOT AVAILABLE FOR COMMERCIAL SALE. This product is not intended to diagnose, treat, cure, or prevent any disease.
Interested in Our Parkinson's Research?
Join our waitlist for clinical trial updates, or explore the Sphere device, our investigational tPCS device for Parkinson's disease.